ACE-031 (Neuromuscular Disease) ACE-031 is a novel, muscle-building agent that is being developed for the treatment of patients with Duchenne Muscular Dystrophy with the goal of improving strength and preserving physical function. What is ACE-031? ACE-031 is an investigational protein therapeutic that builds muscle and increases strength by inhibiting molecules that bind to and signal through a cell surface receptor called Activin Receptor Type IIB (ActRIIB). ACE-031 is a recombinant fusion protein that is produced by joining a portion of the human ActRIIB receptor to a portion of a human antibody. This creates a freely circulating, decoy version of ActRIIB which removes proteins, such as GDF-8 (myostatin) and other related molecules that limit the growth and strength of muscle. Muscle growth is regulated by proteins in the TGF-ß protein superfamily that serve as “on” or “off” switches for muscle production.

Several molecules including GDF-8 interact with the ActRIIB receptor and send an “off” signal to stop muscle production. In the absence of these “off” switch molecules that signal through the ActRIIB receptor, muscle mass increases dramatically. n nature, this effect has been observed in numerous species, particularly in animals that have been bred for increased musculature and strength. For example, Belgian Blue cattle lack the gene for GDF-8, which is one of several molecules that activate the ActRIIB receptor. A deficiency of this protein results in cattle with tremendously developed musculature and strength. Similar effects have been observed in other species, including rodents, dogs and even humans. ACE-031 Builds Skeletal Muscle Treatment with ACE-031 promotes muscle growth by inhibiting ActRIIB signaling.

ACE-031 binds to proteins that signal through the ActRIIB receptor to limit muscle growth. When ACE-031 binds to these proteins, it prevents them from interacting with the ActRIIB receptor, thus allowing muscle to grow. Moreover, because ACE-031 prevents GDF-8 and other proteins that regulate muscle mass from signaling through the ActRIIB receptor, its effects on lean muscle exceed those of inhibitors of GDF-8 (myostatin) alone. When animals are treated with ACE-031, they experience growth in lean muscle and are considerably stronger than their untreated counterparts. This has been shown in several species, and in both healthy animals and in animals with diseases associated with muscle weakness and wasting.

The effects of using ACE-031:

ACE-031 causes a huge increase in muscle mass and muscle strength that can supposedly compete over even the most efficient hardcore volume steroids, such as Oxymetholone.

Taking ACE-031 results in the fast and almost immediate increase of muscle hardness

ACE-031 promotes fat burning

The preferred method of calculation is reconstituting the 1 mg ACE-031 vial with 2 ml sterile water or bacteriostatic water. A little tip here is to clean the top of the vial with an alcohol swab to remove any contamination from bacteria before reconstitution.

You have to inject the 2 ml water in the vial at a very slow pace and leaving it for the powder to absorb the water on its own. You have to be cautious and not to shake the vial for absorption and if still any powder remains unmixed, gradually turn the vial anti-clockwise, so that the remaining powder can get mixed evenly.

The reconstituted solution of ACE-031 should always be refrigerated at around 8 degrees Celsius before and after its use. The solution should not be exposed to direct sunlight or heat as it can change the properties of the solution.